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Non-canonical mRNA cap-binding translation initiation factors in cancer and development, PhD, Faculty of Science, Charles University

Czech Republic (the)

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About Non-canonical mRNA cap-binding translation initiation factors in cancer and development, PhD - at Faculty of Science, Charles University

Human cells contain three eIF4E protein isoforms encoded by separate genes. Each is capable of binding to the 5' mRNA cap and exists in several variants resulting from alternative mRNA splicing. All eIF4E isoforms play important roles in development, cancer and cellular response to stress. Cellular level and activity of the canonical eIF4E1 are tightly regulated by mTOR and Mnk kinases. Overexpression of eIF4E1 can lead to cellular transformation and indeed up to one third of human cancers show an increase in eIF4E1 levels. In addition to its well-recognized role in mRNA silencing and translation in hypoxia, the non-canonical eIF4E2 is one of the proteins whose deregulation creates part of the signature of metastatic cells. In contrast, eIF4E3 has been proposed to act as a tumor suppressor protein. The aim of the proposed project is to use advanced pull-down and chromatography methods followed by LC-MS to purify, analyze and characterize active protein complexes in which the non-canonical members of the eIF4E family occur in human cancer cells, mouse oocytes and early embryos. We offer an enthusiastic team, a well-equipped and well-funded laboratory and close international collaboration with some laboratories at EMBL, Heidelberg.

The candidate should have an expertise in biochemistry and/or molecular biology

Five relevant publications of the research group (lab members are underlined):

Iyyappan, R., Aleshkina, D., Ming, H., Dvoran, M., Kakavand, K., Jansova, D., Del Llano, E., Gahurova, L., Bruce, A. W., Masek, T., Pospisek, M., Horvat, F., Kubelka, M., Jiang, Z. & Susor, A. The translational oscillation in oocyte and early embryo development. Nucleic Acids Res (2023), doi:10.1093/nar/gkad996.

del Llano, E., Masek, T., Gahurova, L., Pospisek, M., Koncicka, M., Jindrova, A., Jansova, D., Iyyappan, R., Roucova, K., Bruce, A. W., Kubelka, M. & Susor, A. Age-related differences in the translational landscape of mammalian oocytes. Aging Cell 19 (2020), doi:10.1111/acel.13231.

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Learn more about Non-canonical mRNA cap-binding translation initiation factors in cancer and development, PhD - at Faculty of Science, Charles University

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Entry requirements

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Fees, Funding and Scholarships at Faculty of Science, Charles University

This text facilitates quick navigation of the various types of scholarships but does not provide a full list of rules and policies regulating this field. The granting and payments of scholarships is governed primarily by the Scholarships and Bursaries Rules of Charles University (cuni.cz/UKEN-727.html), the Rules for Granting Scholarships at FSc, and the relevant measures issued by the Dean (natur.cuni.cz/fakulta/studium/bc-nmgr/predpisy-a-poplatky/stipendia; Czech only).

Students may obtain the following scholarships:

  • accommodation bursary;
  • bursary for a student in difficult social circumstances;
  • scholarship for outstanding academic achievement (“mark-based”);
  • bursary in a case worthy of special consideration;
  • bursary to support study abroad;
  • bursary for a CU student in an acutely difficult situation;
  • bursary to support study in the Czech Republic;
  • bursary for excellent research, development, innovation, artistic, or other creative achievements contributing to enhanced knowledge;
  • scholarship for RDI (research, development, and innovation) under special legislation;
  • motivation bursary for 1st year bachelor’s programme students;
  • motivation bursary for 1st year post-bachelor’s programme students;
  • sports bursary;
  • doctoral bursary.

Certain scholarships are granted to students automatically (without student applications), whereas others are granted further to an application (electronic or paper, depending on the type of scholarship). Bursaries are neither taxed nor included in stated income. You can find answers to frequently asked questions regarding scholarships on the Faculty website (natur.cuni.cz/fakulta/studium/helpdesk/faq-stipendia; Czech only).

For more information check our dedicated website.

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